Abstract
Pharmacological, neuroanatomical and electrophysiological studies indicate that the paratrigeminal nucleus (Pa5), a lower brainstem structure, is a component of the baroreflex pathway. The aims were to evaluate the time course of the Pa5 and importance of different regions in the nucleus to cardiorespiratory and baroreceptor functions. The baroreflex function was estimated by reflex heart rate responses to phenylephrine (PE) or sodium nitroprusside (SNP) infusion-produced short team steady-state AP changes. Pa5 lesions were produced by bilateral ibotenic acid microinjections (1 μg/0.1 μl) in the nucleus (Pa5_XB) and cardiovascular parameters were evaluated and compared to sham-lesioned 1 h to 30 days after surgery. The effect of selective lesions of the structure was evaluated 4 days after lesion surgery.
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