Abstract
In samples with high acyl-HSL at m/z 294.2 (concentration above median), C. leptum was significantly more represented (10.22±0.07 vs 9.72±0.19 log/g of feces, P= 0.046). In these samples, there was also a trend towards higher counts in C. coccoides (P= 0.06) and lower counts in E. coli (P = 0.09). Conclusions: Our study showed for the first time that QS driven by acyl-HSLs occurs in human gut microbiota. Moreover, in IBD, acyl-HSLs profile characterized by prominent acyl-HSL at m/z 216.1 and a decrease in acyl-HSL at m/z 294.2 during flare differs from HS. The lack of this acyl-HSL was associated with low counts in Firmicutes. These results invite us to investigate acyl-HSL functional role in dysbiosis onset and in host physiology.
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