Abstract
Statins are blood cholesterol-lowering drugs that exert their effects through inhibiting cholesterol synthesis via the mevalonate pathway. In addition to cholesterol, this pathway produces intermediate products such as farnesyl diphosphate (FPP), geranylgeranyl diphosphate (GGPP), and squalene. It is reported that statins have an antiproliferative effect through depleting FPP and GGPP, suggesting that they could be useful for cancer treatment. Since FPP is located at a branch point between sterol and non-sterol production, squalene synthase (FDFT1) that converts FPP to squalene is thought to have an important role to control the flow of the mevalonate pathway; however, the effects of statins on this branch point remain unclear.
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