P68.12 Inter-Tumor Heterogeneity of CD44 Expression in Non-Small Cell Lung Cancers / EGFR Mutated Lung Adenocarcinomas

Abstract

Epithelial to mesenchymal transition (EMT) is one of mechanisms of acquired resistance (AR) to EGFR-TKIs in EGFR-mutated lung cancers. In our previous study, we observed that homogeneous high CD44 expression will predict emergence of EMT-mediated AR to EGFR-TKIs in lung cancer cell lines with EGFR mutation as represented by HCC4006 and H1975 cells (PMID:30049789). In this study, we examined inter-tumor heterogeneity of CD44 status to evaluate if CD44 can be a potential biomarker with less sampling variation in the clinical setting.