P68.09 Precision Cut Lung Slices Models for Lung Cancer Chemoprevention Investigations

Abstract

Chemoprevention of lung cancer is key to reducing the burden of lung cancer in high-risk populations. However, studying chemoprevention mechanisms currently relies largely on animal models of lung cancer. While these in vivo studies are critical to support chemoprevention clinical trials, they are costly, time consuming, and require large numbers of animals. Precision-cut lung slices (PCLS) address these challenges by retaining the complexity of living tissue while enabling ex vivo studies of pathogenesis.