Abstract
Striatal presynaptic dopamine synthesis is implicated in neuropsychiatric illnesses like schizophrenia but shows considerable unexplained individual variability. We hypothesized that cumulative functional genetic variation in a network of proteins regulating tyrosine hydroxylase (TH), the dopamine synthesis rate-limiting enzyme, would contribute to dopamine synthesis capacity in the living human brain, measured by [18F]-FDOPA PET. Given prior work suggesting sex differences in the regulation of dopamine, we also tested for sex-specific effects.
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