Abstract
MicroRNA miR-218 is a potent expression regulator of genes known to control adolescent prefrontal cortex (PFC) development and is altered in the PFC of adult depressed subjects who died by suicide. miR-218 expression in blood in adolescent and adult male mice positively correlates with miR-218 expression in the PFC and predicts chronic stress-induced social avoidance in adulthood. We find a gradual rise of miR-218 levels in the PFC from early adolescence to adulthood. Here, we assessed (i) miR-218 levels in females over PFC development, (ii) whether miR-218 levels in blood match expression brain.
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