Abstract
Chronic pain is common worldwide, with devastating social and public health costs. Many psychiatric conditions are commonly comorbid with chronic pain, which can negatively affect treatment outcomes for either condition. Mechanisms of chronic pain development are not fully understood, and treatment is often ineffective. Recent large (N∼480k) GWAS have shown that chronic pain is a complex, polygenic trait with significant CNS involvement, and multiple genetic variants have been associated. However, any functional impact and causal role of these trait-associated genetic variants are not yet known.
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