P600. TAT-SAPIP Reverses Cognitive and Electrophysiological Deficits in Src+/- Mice

Abstract

Sarcoma tyrosine kinase (Src) is a hub for signaling mechanisms affecting NMDA GluN2 phosphorylation and is disrupted by convergent alterations of various schizophrenia susceptibility pathways. We recently showed reduced mismatch negativity and memory in mice heterozygous for the Src gene (Src+/- mice). Src Associated Protein Interfering Peptide (TAT-SAPIP) is a cell-penetrating peptide that disrupts PSD-95–Src association, increasing Src activity in synaptic membranes and enhancing hippocampal GluN currents.