P60-T STN DBS in Parkinson’s disease: EEG microstates analysis

Abstract

Background The therapy in Parkinson’s disease (PD) by deep brain stimulation (DBS) is sometimes complicated because of adverse neuropsychiatric side effects. In our study with three-stimulus visual oddball paradigm (Bockova et al., in prep.) we identified three subgroups of PD patients. Same subgroups can be found in changes of microstates parameters in EEG resting-state data during DBS ON and DBS OFF state. Methods We acquired scalp 256-channel EEG resting-state data from 18 PD patients with DBS of subthalamic nucleus (STN) and 18 age-matched HC. We analyzed resting-state data of 5 min (PD DBS ON, PD OFF, HC). The data were preprocessed in MATLAB (bandpass filtering 1–40 Hz, independent component analysis for cardiac and eye-blinking artefact suppression, interpolation of bad channels). Cartool was used for EEG microstates analysis. Differences in calculated microstate parameters between subject groups was tested by ANOVA. Results Four template maps (A, B, C, D; Britz et al., 2010) explaining 75.21% of global variance were identified. ANOVA testing revealed statistically significant differences in parameters mean duration, time coverage and occurrences per second for C map between HC and PD. Moreover, all parameters of A and D map were significantly different in the context of PD subgroups identified in Bockova et al., in prep. Conclusions We showed that the diversity related to motor-cognitive performance in PD patients with STN-DBS observed during performance of oddball paradigm is reflected also in significant differences in microstates parameters in the resting-state data. Significant differences in parameters can be found also between PD and HC.