Abstract
Cannabinoids are cell membrane-derived signalling molecules that are released from nerves, blood cells and endothelial cells, and have diverse biological effects. Endogenous cannabinoids and their cannabinoid CB1 and CB2 receptors, are present from the early stages of gestation and play a number of vital roles for the developing organism. The majority of afferent neurons have vanilloid VR1 receptors. The aim of this work was to immunocytochemically investigate the development of the neurons containing CB1, CB2 and VR1 receptors in the nodose ganglion of vagus nerve (GNVN), in the spinal ganglia (SG) and sympathetic ganglia of rats of different ages.
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