Abstract
Thoracic SMARCA4-deficient undifferentiated tumor (UT) is one of the high-grade malignancies, affecting smokers. There have been no effective therapies so far. Inactivating mutations of SMARCA4 (BRG1) can yield a truncated protein and may be involved in their malignant transformation. Their comprehensive genomic profiling also shows high tumor mutation burden (TMB) indicative of smoking. A 41-year-old man developed a bulky tumor in the left posterior mediastinum in 2017. At a previous hospital, PET/CT scan displayed 18F-FDG-avid mass (10cm size) with significant thoracic involvement (T4, pulmonary hilum, great vessels, large airways), N3 (bil.
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