P6.046 Pattern of benzodiazepines utilization in the population of elderly treated in their homes

Abstract

Nigella damascena seeds were treated (5 hr) with solutions of different benzodiazepines. Chromosome damage was observed at the first mitosis after the onset of germination. At doses ranging from 12.5 to 50 μg/ml, no effects could be detected with the following substances: bromazepam, oxazepam, medazepam, prazepam, clonazepam and camazepam. Nitrazepam was ineffective at doses of up to 250 μg/ml. At doses ranging from 12.5 to 50 μg/ml, the following substances showed a linear dose-effect relationship: lorazepam, flunitrazepam and chlordiazepoxide as well as diazepam to 250 μg/ml. A proportion of damage was localized to constrictions. After diazepam, some aneuploid cells were found which are presumed to have arisen from chromosome non-disjunction.