Abstract
Evidence indicates that muscarinic acetylcholine receptor agonists exhibit antipsychotic properties. Xanomeline, a centrally active M1 and M4 receptor agonist, is devoid of any direct dopamine receptor affinity or activity. An important question is whether xanomeline can also augment the effects of existing antipsychotics. Two rodent behavioral models were used to test combinations of xanomeline and either risperidone or aripiprazole. The conditioned avoidance response (CAR) and psychostimulant-induced locomotor activity (LMA) assays are commonly used behavioral tests in rodents that have good predictive validity for detecting antipsychotic activity.
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