Abstract

The presence and significance of risk factors of schizophrenia at the population level are debated. Herein we replicate the two recently found neuroanatomical signatures of schizophrenia from the PHENOM consortium—first with widespread reductions of gray matter volume and second with increased striatal volume—and investigate their presence in population-level samples. We further examine their association with psychosis spectrum symptoms (PS), cognition, and schizophrenia genetic risk.

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