P5736Mortality in infarct-related cardiogenic shock patients treated with an microaxial pump: influence of timing and predicted risk

Abstract

Abstract Background In-hospital mortality in acute myocardial infarction-related cardiogenic shock (AMI-CS) remains high at ∼40%. No prospective trials have been finished investigating the influence of mechanical support in AMI-CS. We compared observed to individually predicted mortality using CardShock-, Shock II-, and SAVE-scores in AMI-CS patients treated between 2013 and 2017 with an Impella microaxial pump, who met the IABP-Shock II-trials inclusion/exclusion criteria in order to determine whether standardised use of an Impella microaxial flow-pump in AMI-CS is associated with lower than predicted mortality rates and whether timing of implantation or selecting patients based on predicted risk is meaningful. Methods We analyzed data from 166 consecutive AMI-CS patients meeting the inclusion/exclusion criteria of the IABP-Shock II-trial (age 65±12 years), who received an Impella microaxial pump and compared observed vs. individually predicted mortality using CardShock-, Shock II-, and SAVE-scores. 39% (n=65) had been resuscitated before Impella implantation. Results Overall 30-day mortality was 43%. Mortality was higher in resuscitated patients (50% vs. 36%, p=0.0324) and when Impella was implanted post-PCI (Impella-pre-PCI: 29%, Impella-post-PCI: 50%, p=0.0130). In all score systems predicted mortality was significantly higher than observed mortality on Impella support for individuals with highest predicted risk (IABP-Shock II predicted 77% vs observed 44%, p=0.010; CardShock predicted 77% vs observed 51%, p=0.017; SAVE predicted 81% vs observed 56%, p<0.001). Conclusion In the absence of prospective trials, our retrospective analysis encourages the use of active mechanical circulatory support by Impella microaxial pumps in high-risk patients with AMI-CS and supports the concept of early implantation prior to PCI.