P572. A Role for Sleep in the Relationship Between Thalamocortical Dysconnectivity and Psychosis-Risk Symptoms in 22q11.2 Deletion Syndrome

Kathleen O'Hora,Charles Schleifer,Amy Lin,Leila Kushan-Wells,Carrie Bearden

doi:10.1016/j.biopsych.2022.02.809

P572. A Role for Sleep in the Relationship Between Thalamocortical Dysconnectivity and Psychosis-Risk Symptoms in 22q11.2 Deletion Syndrome

Kathleen O'Hora, Charles Schleifer + Show 3 more

https://doi.org/10.1016/j.biopsych.2022.02.809

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Journal: Biological psychiatry

Publication Date: Apr 28, 2022

Affiliation: University of California, Los Angeles

#Recurrent Copy Number Variant #Increased Sleep Disturbance + Show 8 more

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Abstract

22q11.2 deletion syndrome (22q11.2DS) is a recurrent copy number variant (CNV) with greatly elevated risk for psychosis. A recent study reported that increased sleep disturbance in 22q11.2DS is associated with worse psychosis-risk symptoms. One potential brain mechanism underlying this finding is thalamocortical coupling, which is altered in both 22q11.2DS and schizophrenia.

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