Abstract
Objective Since the first use of bromide as an anti epileptic drug (AED) and the introduction of the third generation AEDs in the early 90s, a continuous effort is provided to develop efficient and easy to administer AEDs. Despite this continuous progress, many AEDs are for adults and the galenic forms is often not adapted for a use in the pediatric population. Methods We collected all prescriptions done in a tertiary centre (Centre de reference des epilepsies rares, Necker Enfants Malades Hospital) in 2012. We analysed the demographic datas, seizure type, and the epileptic syndrome in correlation with unlicensed usage, off label usage and manipulation of AEDs done by the parents. Datas were statistically analyzed on SPSS. Results We report use of unlicensed AED in 26%, in accordance with litterature data. The off label use was important, concerning 50% of the prescribed medications. It was mainly in young children (0 to 6 years) and in epileptic encephalopathies like Dravet syndrome. Conclusion This study highlights the need for the development of galenic form of AEDs adapted to children in order to minimize the risk of error in dosage and administration of these drugs.
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