P559. Hippocampal Network Dysfunction in Early Psychosis: A Two-Year Longitudinal Study

Abstract

Functional dysconnectivity, the loss of coherence of functional networks, is considered a hallmark feature of schizophrenia. In the early course of illness, studies have found mixed evidence of both hyper- and hypoconnectivity for individual hippocampal connections. At this point, it is unclear whether the overall hippocampal network is hyper- or hypoconnected in the early stage of psychosis, and whether connectivity changes with illness duration. Here, we use graph theory to test the hypothesis that hippocampal network coherence is low in early psychosis and progressively worsens over two years.