P557. Mutations in Kalrn Disrupt Gamma-Band Oscillations in the Auditory Cortex of Adult Mice

Abstract

Neuropsychiatric disorders such as schizophrenia exhibit disordered sensory cortical function. Dendritic and synaptic impairments may form the basis of such dysfunction. The KALRN gene codes for multiple isoforms that serve various roles in regulating dendritic and synaptic biology. Modeling a naturally occurring mutation in Kalrn (Kalrn-PT mouse model) that affects the longer, dual active domain isoforms, recapitulated an adolescent-onset reduction in dendritic length and complexity in Layer 3 pyramidal neurons in the primary auditory cortex (A1).