Abstract
In lung cancer, the RB1-CCND1-CDKN2A pathway, involved in the G1-S transition, has an especially crucial role in tumorigenesis. This region harbors another important partner in the RB1-CCND1 pathway, namely, cyclin dependent kinase 4 (CDK4). The aim of this study is to investigate mutations and prognosis of non-small-cell lung cancer (NSCLC) harboring CDK4 mutations.
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