Abstract
Neuromelanin (NM) is a product of monoamine metabolism including dopamine (DA). NM-sensitive MRI sequences allow in vivo quantification of NM levels in the substantia nigra (SN). NM-MRI signal is thought to serve as a biomarker for SN dopamine neuron integrity, and in turn, striatal DA functioning. Increased striatal DA synthesis has been associated with response to first-line antipsychotics (FLR) in patients with schizophrenia, while normal striatal DA synthesis has been associated with treatment-resistant schizophrenia (TRS).
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