Abstract
The study was designed to evaluate the prognostic importance of clinical and pathologic variables withp53andBcl-2in epithelial ovarian cancer using multivariate analysis. Tumor tissues from 90 patients were analyzed immunohistochemically forp53andBcl-2expression. Hazard ratios were calculated in univariate and multivariate survival analyses. Forty-two (47%) were considered positive forp53expression and 18 (20%) were positive forBcl-2. Positive expression forp53was less frequent in patients in FIGO stage I (22%). Positive staining forBcl-2correlated significantly with the histologic type (P< 0.01). No direct correlations could be demonstrated betweenp53andBcl-2expression and age or histologic grade. In univariate analysis,p53andBcl-2expression were not significantly correlated with overall survival, disease-free survival, or progression time. FIGO stage III and IV and residual disease ≥2 cm3after first surgery were significantly correlated with poor outcome in univariate analysis. FIGO stage retained their independent prognostic value in multivariate analysis. Neitherp53norBcl-2had any significant influence on outcome in multivariate survival analysis. FIGO stage proved to be the only significant independent prognostic factor in epithelial ovarian cancer, although residual disease remains correlated with disease-free survival.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
