P532. Smoking as a Common Modulator of Sensory Gating and Reward Learning in Individuals with Psychotic Disorders

Abstract

Motivational and perceptual disturbances co-occur in psychosis and have been linked to aberra-tions in reward learning and sensory gating, respectively. Although traditionally studied inde-pendently, when viewed through a predictive coding framework these processes can both be linked to dysfunction in striatal dopaminergic prediction error signaling. This study examined whether reward learning and sensory gating are correlated in individuals with psychotic disor-ders, and whether nicotine – a psychostimulant that amplifies phasic striatal dopamine firing – is a common modulator of these two processes.