Abstract
Brain-based interventions are needed to address persistent relapse in alcohol use disorder (AUD). Our neuroimaging evidence showed that long-term abstinent AUD individuals have higher frontal-striatal resting state functional connectivity (rsFC) vs short-term abstinent AUD and controls. Low frontal-striatal rsFC during early abstinence predicts subsequent relapse. A longitudinal double-blind randomized clinical trial investigated whether a non-invasive neuromodulation intervention during early abstinence can (1) modulate frontal-striatal rsFC and (2) is associated with treatment outcomes.
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