P53 Gene Codon 72 Polymorphisms among Cervical Carcinoma Patients

Abstract

Objective: To identify the association between p53 gene codon 72
 polymorphism and cervical carcinoma.
 Method: An analytic observational study with case-control design,
 from November 2013 until March 2014 in the Department of Obstetrics
 and Gynecology and Microbiology Laboratory Faculty of Medicine,
 Sriwijaya University, Dr. Moh. Hoesin Hospital Palembang.
 Result: In total there are 100 samples analyzed consisting of 50 subjects
 and 50 control groups. Genotype distribution in subject group
 are 54% Arg/Arg, 42% Pro/Arg and 4% Pro/Pro, and in control
 group are 36% Arg/Arg, 46% Pro/Arg and 18% Pro/Pro. Arg/Arg
 genotype is at risk of cervical carcinoma 6.7 times higher compared
 with Pro/Pro genotype (p=0.013; OR 6.75; 95% CI 1.34-34.94). Arg
 allele in the p53 gene codon 72 increase the risk of cervical carcinoma
 2.6 times more than Pro allele.
 Conclusion: Proline mutation to Arginine in gene p53 P72R is one of
 the risk factor for cervical carcinoma.
 
 Keywords: arginine, cervical carcinoma, gene p53 codon 72, polymorphism,
 proline