P53 and cancer metabolism

Abstract

<p indent="0mm">p53 has actions in cell cycle inhibition, induction of cell senescence and apoptosis and plays a role in tumor suppression. p53 has been reported to influence redox homeostasis and metabolic stability and also to mediate intracellular ferroptosis, thereby affecting the growth of cancer cells. Metabolic reprogramming of tumor cells is also modulated by p53 with resultant tumor inhibition. However, mutant p53 has altered metabolic regulatory functions from the wild-type protein and tumor inhibitory activity may be impaired. The current study reviews the metabolic regulatory activity of p53 and its involvement in the oxidative stress response and autophagy process in tumor cells. Post-translational modification of p53 and the functional changes of mutant p53 in tumor cells are discussed. Key roles of p53 in regulation of tumor metabolism are analyzed. The aim was to provide reference materials to aid the understanding of p53 regulatory functions and anticancer roles for research purposes.