Abstract
Sporadic inclusion body myositis (sIBM) is a common inflammatory muscle disease in elderly person. Outstanding feature of sIBM is the presence of rimmed vacuoles (RV) revealed by modified Gomori trichrome staining and multiprotein aggregates made of amyloid β (Aβ) and ubiquitin in muscle fibers. RV are considered autophagic, since they often contain lysosomal membranous debris, an end product of muscle-fiber digestion, and increased immunoreactivity of some of the lysosomal enzymes. Autophagy is implicated in not only sIBM but also some frontotemporal dementia (FTD).
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