P498. Intact Implicit Reinforcement Learning in Schizophrenia and Youth at Clinical High-Risk for Psychosis

Abstract

Negative symptoms (e.g., amotivation) are prominent in schizophrenia (SZ). These symptoms begin early in the course of the disorder, including in youth at clinical high-risk for psychosis (CHR) with subthreshold psychotic symptoms. In SZ, negative symptoms are linked to reward-based learning dysfunction. However, previous research suggests implicit reinforcement learning remains intact in SZ. It is unknown whether CHR individuals also have preserved implicit reinforcement learning, knowledge of which may help clarify mechanistic pathways of negative symptoms and psychosis risk.