Abstract
Inhibitory effects of hydrogen sulfide (H2S) on the smooth muscle motility of the ileum and the colon have been reported. However, it is unclear whether H2S can affect the esophageal motility. Therefore, the aim of the present study was to clarify the effects of H2S on the motility of the esophageal striated muscle in the rat. An isolated segment of the rat esophagus was placed in an organ bath and the mechanical responses were recorded using a force transducer. Electrical stimulation of the vagus nerve evoked the contractile response in the esophageal segment. The vagally mediated contraction was inhibited by application of a H2S donor, NaHS. NaHS did not affect the contraction induced by electrical field stimulation, which directly can excite the striated muscle not via vagus nerves. This shows that H2S can influence not directly the striated muscle but neurons. RT-PCR revealed the expression of CBS and CSE mRNA in the esophageal tissue. These findings suggest that H2S might be produced in the esophageal tissue and might regulate the motility of the esophageal striated muscle.
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