Abstract
Dopamine and excessive pruning of neuronal extensions are consistently associated with the pathophysiology of schizophrenia (SCZ). Dopamine participates in several aspects of brain development including pruning of neuronal extensions. It is therefore possible that patients with SCZ carry an increased susceptibility to dopamine’s pruning effects and that this susceptibility would be more obvious in the early stages of neuronal development when dopamine pruning effects are more evident. We used Monocyte-Derived-Neuronal-like Cells (MDNCs) to test our hypothesis as these cells reproduce several characteristics of human developing neurons. In addition, MDNCs can be generated rapidly and deliver reproducible results.
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