P48 Haematopoietic but not mesenchymal stem cells contribute to the stromal microenvironment in cholangiocarcinoma and do not transdifferentiate into malignant bile ducts

Abstract

AimCholangiocarcinoma (CC) is characterised by a pronounced inflammatory stroma consisting of tumour associated myofibroblasts, macrophages, immune cells and a modified extracellular matrix. Furthermore, in animal models of gastric cancer, reports...