Abstract
Resistance to first(1st), second(2nd) and third (3rd) generation of tyrosine kinase inhibitors(TKIs) in EGFR mutant NSCLC targeted therapies can be classified as either primary (i.e., intrinsic) or secondary (i.e., acquired). Primary resistance implies a de novo lack of response whereas secondary resistance refers to disease progression after a period of initial clinical benefit.Next generation sequencing(NGS) offers a comprehensive method of detecting these mechanisms to decide the next line of treatment.
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