Abstract
1998 and 2012 and examine their all-cause hospitalisations. HE patients were matched to controls at a ratio of 1:1 by age, gender, year of diagnosis, duration and severity of liver disease. Hospital admission data (frequency and length of stay) were characterised from HES. Admissions associated with the index diagnosis of HE were excluded. Results: 17,030 patients were identified with an incident diagnosis of liver disease, of whom 551 (3.2%) had a recorded diagnosis of HE. 389 patients (70.6%) could be matched to non-HE controls. Total number of primarily liver-related admissions was greater in the HE group with a crude admission ratio of 3.588 (95%CI 3.085– 4.173, p < 0.001). In the HE group, a significantly greater proportion of liver-related admissions were through A&E (62.1% versus 50.0%, p < 0.001) and mean length of stay was 8.0 days (sd 11.6) vs 6.8 days (sd 9.5) (p = 0.148) in the non-HE group. Following first HE event, patients had 18.2 primary care contacts per patient year compared with 8.7 for non-HE controls (p < 0.001). Conclusions: HE was associated with increased risk of liver-related hospital admissions, and increased GP attendances.
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