P479. Diagnostic and Laminar Differences of GAD67 and GAD65 Transcript Levels in the Dorsolateral Prefrontal Cortex

Abstract

Levels of GAD67 and/or GAD65 mRNAs, which encode GABA synthesizing enzymes, have been reported to be lower in the dorsolateral prefrontal cortex (dlPFC) from individuals with schizophrenia (SCZ), bipolar disorder (BP), or major depression (MD). However, few studies have evaluated both transcripts across all 3 disorders. Additionally, most studies have not compared transcript levels between superficial and deep zones of the dlPFC, which differ substantially in their GABA neuron composition. Thus, we quantified GAD67 and GAD65 mRNA expression in both dlPFC zones from subjects with SCZ, BP or MD and unaffected comparison (UC) subjects.