Abstract
Vitamin D has entered the spotlight in the search for preventive treatments against asthma and allergic disease due to its immune-modulating functions, shown in experimental models to include promotion of immune tolerance and boosting protection against infection. Vitamin D inadequacy is common, but disparate findings from cohort studies have had a polarising effect on the scientific community regarding the wisdom of advocating vitamin D supplementation for protection against asthma and allergic disorders. We have previously found that in the high-risk Western Australian CAS cohort (selected due to positive parental atopic history), the combination of multiple severe lower respiratory infections and sensitisation to inhaled allergens by age 2 profoundly increased risk of asthma development by age 5. Aims To determine whether vitamin D levels between birth and age 10 years in the CAS cohort are related to frequency of severe respiratory infections in early childhood, allergic sensitisation, and development of asthma by age 5o r 10 years. Methods
Highlights
Vitamin D has entered the spotlight in the search for preventive treatments against asthma and allergic disease due to its immune-modulating functions, shown in experimental models to include promotion of immune tolerance and boosting protection against infection
We have previously found that in the high-risk Western Australian CAS cohort, the combination of multiple severe lower respiratory infections and sensitisation to inhaled allergens by age 2 profoundly increased risk of asthma development by age 5
Vitamin D3 inadequacy was common amongst cohort participants, and as expected was highest amongst participants from whom blood was collected in winter; deseasonalised vitamin D3 was calculated for longitudinal comparisons
Summary
P47 - Does vitamin D status in childhood modify risk for asthma development by altering susceptibility to severe respiratory infection and allergic sensitisation?. Elysia Hollams1*, Guicheng Zhang, Barbara Holt, Merci Kusel, Peter Sly, Patrick Holt, Prue Hart. From 3rd Pediatric Allergy and Asthma Meeting (PAAM) Athens, Greece. From 3rd Pediatric Allergy and Asthma Meeting (PAAM) Athens, Greece. 17-19 October 2013
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