P466 SCREENING FOR ZINC DEFICIENCY IS NECESSARY IN THE MANAGEMENT OF PATIENTS WITH CIRRHOSIS

Abstract

Methods: Sixty-five patients with cirrhosis tested for ETP with/without TM. Clinical, endoscopic variables, presence/absence of PVT by Doppler-US and/or TC examination were collected at basal evaluation and up to 4 years. The incidence of de novo PVT was the primary clinical end-point. We also considered transplantation freesurvival. ETP-ratio upper than the 95° percentile of 173 healthycontrols defined TM-resistance. Results: ETP-ratio was not different by comparing patients with (n =1 2) vs without PVT (n = 53) at basal evaluation. Among no-PVT patients, 11 developed de novo PVT in the follow-up. The incidence of PVT was higher in those patients with TM-resistance (n = 36) also after adjustment for Child-score (HR:7.68; 90%-CI: 1.32–44.54, p = 0.017). Seventeen patients experienced at least one PHT-related complication and 23 patients died or were transplanted. The mean survival time-free of transplantation was 2.7 vs 3.6 years by comparing, respectively, patients with vs without TM-resistance (p = 0.005, log-rank test). However, only Child-score independently predicted transplantation free-survival. Conclusions: The occurrence of PVT should be explained, in part, by the pro-coagulant imbalance described in patients with advanced liver disease. TM-resistance could be a potential modifiable factor to improve survival in patients with cirrhosis. P465 SVR IS ASSOCIATED WITH NO RISK REDUCTION OF HCC DEVELOPMENT IN PATIENTS WITH HCV-RELATED CIRRHOSIS. A PROSPECTIVE, UP-TO 23 YEARS, COHORT FOLLOW-UP STUDY S. Bruno 1