P-465 Effect of male age on the outcome of frozen embryo trnasfer cycle in women over 40 years

Abstract

Abstract Study question Does male age affect the outcome of in vitro fertilization in women over 40? Summary answer Advanced male partner's age is associated with decreased pregnancy rate, implantation rate and ongoing pregnancy/live birth rate. What is known already Fertility is known to have the greatest correlation with female age. Older women have a relatively lower pregnancy rate and higher miscarriage rate. It is also widely known that male partner's age is associated to pregnancy rate with increased sperm DNA fragmentation and decreased sperm motility. Age of marriage is delayed both male and female partners, assisted reproductive techniques are often conducted in women over 40 years. The effect of male age on IVF/ICSI outcomes on women over 40 is poorly explored. Study design, size, duration This is a retrospective cohort study analysed 1046 cycles of couples with an age of 40 or more of female partners and their male partners, performed at a single IVF center of university hospital between 2019 and 2022. The primary outcome was ongoing live birth and secondary outcomes were clinical pregnancy and miscarriage. Participants/materials, setting, methods Couples of primary/secondary infertility with female partner age over 40 years who underwent frozen-embryo transfer cycles were selected. couples who collected their sperm from TESE/TESA were excluded. Main results and the role of chance We decided the male partner's age in three groups, age less than 40, 41-45, and age over 45. There was a negative effect of male age on ongoing live birth and clinical pregnancy rate.(20.0%, 10.3%, 10.9%, p < 0.001, 33.7%, 28.4%, 19.9%, p = 0.017). And we sub-analyzed ongoing live birth rate and clinical pregnancy rate into female age group(female age of 40, 41-42, and over 43). The ongoing pregnancy/live birth rate and clinical pregnancy rate were negatively associated with male partner's age especially in female age group of over 43 years. Limitations, reasons for caution This study is limited to the information on confounding factors. The study may also be limited due to its selection criteria. Wider implications of the findings This study provides information regarding IVF/ICSI outcomes on women over 40 years of age Trial registration number not applicable