P46 – 2873: Frequency of rescue medication administration and its effect on seizure duration in a European survey of children with epilepsy who experience prolonged acute convulsive seizures

Abstract

Objective To compare parent-reported seizure duration with and without rescue medication in children with epilepsy who have prolonged acute convulsive seizures (PACS). Methods Practices in Emergency and Rescue medication For Epilepsy managed with Community-administered Therapy 3 (PERFECT-3) was a cross-sectional study conducted in Germany, Italy, Spain and the UK. Eligible patients were non-institutionalized children aged 3–16 years who had been diagnosed with epilepsy ≥12 months previously, had experienced ≥1 PACS within the last 12 months and had currently prescribed rescue medication(s) for PACS. Investigators provided clinical assessments and parents/guardians completed web-based questionnaires. Statistical tests were post hoc; p values are descriptive, non-inferential and uncorrected for multiple comparisons. Results At baseline, most of the 286 enrolled patients had prescriptions for diazepam (69.2%) or midazolam (55.9%), and some had two (26.6%) or three (2.4%) prescribed rescue medications. Parents reported that the average length of children's prolonged seizures without rescue medication was 0 to Conclusions In this parent-reported survey of children with epilepsy who had ≥1 PACS in the previous year, significantly more children's seizures lasted