Abstract
Introduction Motor neurone disease, characterised by upper and lower motor neuron degeneration, affects muscle at the superficial and deeper levels. Motor function can be evaluated non-invasively using TMS, recording surface EMG that is useful but limited by access to deeper muscles. Ultrasound can provide a broader view of these muscles, although it is unknown whether we can use US to measure TMS muscle contraction. We hypothesise that there will be a positive correlation between EMG and US measures, in a healthy population. TMS-US is important as a potential tool for examining MND patients, with degenerative onset in muscles that are difficult to probe with EMG. Methods TMS was applied to Left-M1 & USs this requires further replication. We can pick up muscle contraction at 20% earlier with ultrasound (t = 0.16). Conclusion TMS combined with US complements EMG. TMS can be used where EMG can be challenging such as the tongue or deeper muscles. Future work will expand this to other standards of TMS protocol.
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