Abstract
Williams syndrome (WS), a neurodevelopmental disorder caused by hemideletion of ∼25 genes in chromosomal region 7q11.23, is associated with increased social drive and reduced visuospatial construction abilities. Previous neuroimaging studies in adults and children with WS have identified alterations in cortical and DTI-based white matter properties in brain regions associated with these behavioral and cognitive characteristics, and recent research has indicated that myelination may also be altered in WS. We studied spatiotemporal distributions of myelin water fraction (MWF) in longitudinally-scanned children with WS as well as typically developing (TD) children.
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