P441. Working Memory Impairment is Associated With Altered Brain Morphometry and Structural Connectivity in Children and Adolescents With Chromosome 22q11.2 Deletion Syndrome

Abstract

Working memory (WM) impairment contributes to learning difficulties and may be a risk indicator for later mental illness in people with neurodevelopmental disorders like chromosome 22q11.2 deletion syndrome (22q11.2DS). Neural activation associated with WM processing shifts from parietal to frontal regions throughout age in the neurotypically developing brain. In children with 22q11.2DS, however, activation is restricted to the frontal cortex, and parietal development is atypical. The aim was to determine neurocorrelates of WM in children with 22q11.2DS.