P44 – 2863: Clinical and radiological factors associated with later occurence of epilepsy and epileptic encephalopathy after hypoxic ischemic insult

Abstract

Objective Epileptic encephalopathy is a devastating type of epilepsy in early life causing severe cognitive and behavioral impairments. Epilepsy and epileptic encephalopathies may be complications of hypoxic ischemic encephalopathy during the neonatal period. Methods In this retrospective study 60 patients who suffered hypoxic ischemic encephalopathy in the neonatal period; aged 6.75±5.34 (0.30–12.09) years, 28 girls (46.7%) and 32 boys (53.3%) were invastigated to describe clinical and radiological factors associated with later occurence of epilepsy and epileptic encephalopathy were divided in 3 groups. Group 1: Patients with epileptic encephalopathy (n: 27 (%45) Group 2: Patients with epilepsy without encephalopathy (n: 18 (%30). Group 3: Patient without epilepsy and epileptic encephalopathy (n:15 (%25). Groups were compared for prenatal, natal and postnatal insults, neonatal seizures, cranial USG, electroencephalography (EEG) in neonatal period and cranial Magnetic Resonance Imagination (MRI). Results Gestational ages and birth weights of group 3 were lower then Group 1 and Group 2 (p Conclusion Higher asphyxia grades, neonatal menengitis and sepsis, cortical impairment in cranial MRI, seizures in the neonatal period are high risk factors for evaluation of epilepsy and epileptic encephalopathy in children suffered from HIE in neonatal period.