P4399Low social support and risk of myocardial infarction in general population in Russia/Siberia: gender disparities. WHO epidemiological program MONICA-psychosocial study

Abstract

Abstract Aim To determine the gender differences in the effect of social support on risk of myocardial infarction (MI) in an open population 25–64 years in Russia/Siberia. Methods Under the third screening of WHO program MONICA-Psychosocial a random representative sample of both gender aged 25- 64 years in Novosibirsk was examined in 1994 (n=1346, males 48.8%, mean age 44,9±0,4 years). Indices of close contacts (ICC) and social relations (SNI) were evaluated at the baseline by Berkman-Syme test. New-onset MI incidences were identified over 16-years (1994–2010yy) of follow-up in the cohort. Results The prevalence of low ICC levels was higher in men compared to women (63.9% and 57.1%, respectively); the prevalence of low SNI levels was higher in women compared to men (77.7% and 43%, respectively). The risk of MI over 16 years of follow-up was 5.2-fold higher in men (95% CI 1.947–19.383; p<0.05) and4.9-fold higher in women (1.108–21.762; p<0.05) with low ICC. Low SNI increases risk of MI in 3.1 times in men (1.138–9.247; p<0.05) and in 2.9 times in women (95% CI 1.040–8.208; p<0.05). After adjustment for social variables multivariate model showed significant results in higher risk of MI in those males who are living alone with manual occupational status and in women with low educational degree. Conclusions Social support is a protective factor for MI incidence both in men and women. Better social gradient improves this influence. Family status and occupation are stronger to be attributable to risk in males while level of degree in females with low social support.