P435 Plasma inflammation-related proteins as markers of anxiety and depression disorders in inflammatory bowel disease patients

Abstract

Abstract Background Up to 25%-35% of patients with inflammatory bowel disease (IBD) suffer from anxiety or depression. Inflammatory and immune response processes may play an important role in the co-occurrence of IBD and mood disorders. We aimed to investigate the plasma inflammation-related proteins that can characterize the anxiety and depression disorders in IBD patients. Methods Plasma was collected from 61 IBD patients, and the OLINK panel (Target 96 Inflammation) was used to quantify the expression levels of 92 inflammation-related proteins. The Hospital Anxiety and Depression Scale (HADS) was used to assess the anxiety and depression symptoms. Results Among the involved IBD patients (median age 37, 40.98% female), 26.23% had anxiety and 29.51% had depression. Compared with IBD patients without mental disorders, the plasma level of FGF-23 was significantly increased in IBD patients with anxiety or depression disorders (P=0.035). Besides, the levels of CCL20 (P=0.039) and CXCL1 (P=0.021) were up regulated in IBD patients with anxiety and depression, respectively (Figure 1). Correlation analysis showed that the plasma level of CXCL1 (r=0.254, P=0.047) and FGF-23 (r=0.318, P=0.012) were positively correlated with the total degree of anxiety and depression disorders, while DNER (r=-0.300, P=0.018) appeared a reverse correlation trend. On the other hand, the plasma level of FGF-23 (r=0.351, P<0.01) was positively correlated with anxiety degree in IBD patients. As for the depression disorder, we found a positive correlation in plasma CXCL1 (r=0.296, P=0.020) level, and negative correlations were found in levels of IL-8(r=-0.256, P=0.045), uPA (r=-0.264, P=0.038), IL-20 (r=-0.290, P=0.022) and DNER (r=-0.353, P<0.01) (Figure 2). Conclusion We found specific plasma inflammation-related proteins for anxiety and depression disorders in IBD patients. The high incidence of anxiety and depression in IBD patients may be attributed to the stimulation of high levels of inflammatory factors.