Abstract
The pubertal transition is associated with increased cognitive control. Adrenarche, the activation of the adrenal androgenic endocrine system, plays an important role in puberty. However, the impact of adrenal androgens, including dehydroepiandrosterone sulfate (DHEAS), on neurodevelopment has been difficult to disambiguate from that of gonadal hormones. To investigate adrenarche-specific changes in prepubertal brain function, we studied typically-developing children who were carefully documented to be prepubertal, and thus had no puberty-related increases in gonadal hormones, to examine the impact of DHEAS on brain activation associated with inhibitory control.
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