Abstract
Numerous studies have shown that diabetic heart is characterized by compromised ventricular contraction and prolonged relaxation attributable to multiple causative factors especially oxidative stress. Hydrogen sulfide (H2S) has cardioprotective effects. This study was designed to investigate S-propargyl-cysteine (SPRC), an H2S donor, as well as its effect on the progression of heart-protective effectinStreptozotocin-Induced Diabetic Ratsand underlying mechanisms. Fifty male Sprague–Dawley Rats (5 groups, n = 10) were grouped into the normal control, diabetic control and low, moderate, and high doses of SPRC-treated groups. Six weeks later, SPRC-treated rats showed a significant alleviation in the development of heart dysfunction in a dose-dependent manner. Plasma H2S level and cystathionase-γ-lyase (CSE) activity in the ventricular tissues, determined by spectrophotometer, were significantly higher in SPRC-pretreated group. SPRC increased the Left ventricular mass index, the left ventricular systolic pressure and the maximum rate of pressure and decreased left ventricular end-diastolic pressure. In addition, Marginal changes in the lipid parameters were found in the SPRC-treated rats, with advanced glycation end products (AGES), triglyceride (TG) and high-density lipid cholesterol (HDL-C) elevation reduction at the high dose. In addition, SPRC also dose-dependently increased the total antioxidant capacities and in parallel decreased the lipid peroxidation levels in the serum and the left ventricular. The antioxidant effects of SPRC were implicated by the enhanced activities of catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx) and levels of glutathione (GSH) in the serum, as well as the mRNA levels of CAT, SOD-1 and GPx in the left ventricular. On the other hand, SPRC treatmented dose-dependently reduced levels of serum lactate dehydrogenase (LDH) and malondialdehyde (MDA). In a streptozotocin-induced diabetic rat model, SPRC dose-dependently ameliorated the progression of cardiac vascular dysfunction accompanied by the suppression of oxidative stress. These findings suggested that SPRC might be a potential agent for the treatment of diabetic heart dysfunction. Download : Download full-size image
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