P424. Epigenetic Intergenerational Transmission: Mothers’ Adverse Childhood Experiences and DNA Methylation

Abstract

Individual differences in risk for mental disorders over the lifespan are shaped by forces acting before the individual is born— in utero, but likely even earlier, during the mother’s own childhood. In the current study, we tested whether mothers’ adverse childhood experiences (ACEs) are correlated with DNA methylation (DNAm) in peripheral blood during pregnancy and in cord blood samples from newborn infants.