P416. Cerebral Blood Flow and Cardiovascular Risk Factor Effects on Resting Brain Regional Homogeneity

Bhim M Adhikari ,Theo G.M Van Erp,Danny J.J Wang,Xiaoming Du,Heather Bruce,Shuo Chen,Vince D Calhoun,Joshua Chiappelli,L Elliot Hong,Mark D Kvarta,Peter Kochunov,Zhiwei Zhao,Neda Jahanshad,Eric L Goldwaser,Yizhou Ma ,Jessica A Turner ,Thomas E Nichols ,Stephanie Hare ,Alyssa Zhu ,Paul M Thompson ,Kathryn S Hatch

doi:10.1016/j.biopsych.2022.02.652

P416. Cerebral Blood Flow and Cardiovascular Risk Factor Effects on Resting Brain Regional Homogeneity

Bhim M Adhikari , Theo G.M Van Erp + Show 19 more

https://doi.org/10.1016/j.biopsych.2022.02.652

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Journal: Biological psychiatry

Publication Date: Apr 28, 2022

Affiliation: University of Maryland, Baltimore, University of California, Irvine, University of Southern California, Georgia Institute of Technology, Georgia State University, Center for Translational Research in Neuroimaging and Data Science, Emory University, University of Maryland, College Park, University of Warwick

#Fluctuations In Cerebral Blood Flow #Cerebral Blood Flow + Show 8 more

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Abstract

Regional homogeneity (ReHo) is a local synchronization index computed from brain resting state functional MRI timeseries and has been proposed as a measure of local functional connectivity. ReHo abnormalities are reported in a wide range of neurological and psychiatric disorders. However, ReHo measure is sensitive to local fluctuations in cerebral blood flow (CBF) that is in turn influenced by system-level cerebrovascular health. We hypothesize that ReHo signal may be influenced by CBF in a regionally specific way; and the latter is affected by the global cardiovascular factors.

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