P41.01: Uterine arteries blood flow comparison in 11 + 0 to 13 + 6 weeks of pregnancy after natural and ART conception

Abstract

To evaluate uterine arteries Doppler pulsatile index (PI) and resistance index (RI) at 11 + 0 to 13 + 6 weeks of singleton pregnancies with good known outcome after natural and assisted reproductive technologies (ART) conception, to continue this work for later retrospective analysis in cases with obstetrical complications and poor neonatal outcome with the idea to use first trimester prenatal anomalies screening program for obstetrical goals. All patients both with natural pregnancies and with pregnancies after ART conception underwent transabdominal uterine artery Doppler flow velocimetry to measure the PI and RI in addition to a first-trimester prenatal chromosomal anomaly screening program in a one-stop clinic for assessment of risk (OSCAR). After delivery, a retrospective analysis was done to compare Doppler measurements in late first trimester in pregnancies with known good outcome. There were 36 cases after natural spontaneous conception and 48 cases after ART conception The mean PI were 1.46 in spontaneous pregnancies and 1.43 in ART pregnancies. The mean RI were 0.68 in spontaneous pregnancies and 0.66 in ART pregnancies. An average newborn weight and Apgar was, respectively, 3430 g and 9 in spontaneous conception group. An average newborn weight and Apgar was, respectively, 3320 g and 9 in ART pregnancies group. These results show no differences in uterine arteries Doppler indices between groups with spontaneous and ART conception in pregnancies with known good outcome. It suggests no major differences in trophoblastic invasions between ART and natural pregnancies with good outcome. It needs to evaluate the possible differences of uterine Doppler indices in pregnancies after natural spontaneous and ART pregnancies in cases of known late obstetrical complications.